Tumor Necrosis Factor and Splenectomy
نویسنده
چکیده
Banyatsuppasin et al. suggested the role of the spleen in controlling mononuclear phagocytic activity in E/b-Thal patients [6]. TNF-α play roles as an inducer and effector of monocyte activation [6]. Additionally, TNF-α returned to normal after 12, 6, and 3 months of deferiprone treatment [7]. Therefore, chelation treatment can affect apoptosis independently of splenectomy. It might be important to know the effect of chelation treatment and splenectomy on tumor necrosis factor in the study of Tanyong et al. [1] based on all these investigations stated above [2,3,4,5,6,7].
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